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MMP(-2) expression in skeletal muscle after strength training.

A P L Deus1, D Bassi, R P Simões

  • 1UFSCar, Physiotherapy, Sao Carlos, Brazil.

International Journal of Sports Medicine
|November 19, 2011
PubMed
Summary

Resistance training on ladders (RTL) impacts matrix metalloproteinase-2 (MMP-2) expression and blood lactate. High-intensity RTL significantly increased active MMP-2 and lactate levels, suggesting exercise intensity modulates MMP-2 activity.

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Area of Science:

  • Exercise Physiology
  • Molecular Biology
  • Biochemistry

Background:

  • Matrix metalloproteinase-2 (MMP-2) plays a role in tissue remodeling.
  • Exercise intensity can influence biochemical markers like blood lactate concentration.
  • Understanding MMP-2 regulation during exercise is crucial for sports science.

Purpose of the Study:

  • To investigate the effects of resistance training on ladders (RTL) on MMP-2 expression and blood lactate concentration ([La-]) in rats.
  • To compare the responses between low-intensity and high-intensity RTL protocols.
  • To explore the correlation between active MMP-2 and [La-] during exercise.

Main Methods:

  • 30 male albino rats were divided into sedentary control, low-intensity RTL, and high-intensity RTL groups.
  • Training program involved 3 sessions per week for 8 weeks with progressive overload for the high-intensity group.
  • MMP-2 expression in tibialis anterior muscle and blood lactate concentration were measured.

Main Results:

  • Both low and high-intensity RTL increased pro-form MMP-2.
  • Only high-intensity RTL significantly increased active-form MMP-2.
  • Both training groups showed increased [La-], with significantly higher levels in the high-intensity group.
  • A strong positive correlation (r=0.91) was observed between active MMP-2 and [La-] in the high-intensity group.

Conclusions:

  • Resistance training on ladders (RTL) serves as a valid animal model for studying exercise-induced biochemical changes.
  • Exercise intensity is a key factor in modulating the active form expression of MMP-2.
  • High-intensity exercise significantly elevates both active MMP-2 and blood lactate, indicating a potential link between these markers.