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Effect of altered core body temperature on glottal closing force
Mikhail Wadie1, Juan Li, Clarence T Sasaki
1Section of Otolaryngology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
The Annals of Otology, Rhinology, and Laryngology
|November 22, 2011
Summary
Core body temperature significantly impacts the larynx's protective glottal closure reflex. Increased temperature enhances glottal closing force, while decreased temperature reduces it, suggesting central nervous system regulation.
Area of Science:
- Physiology
- Laryngeal Function
- Neuroscience
Background:
- The larynx provides essential airway protection via a brain stem-mediated glottal closure reflex.
- Glottal closing force, the pressure between vocal folds, is crucial for this reflex.
- Core body temperature is a suspected modulator of the glottal closure reflex.
Purpose of the Study:
- To investigate the relationship between core body temperature and glottal closing force.
- To determine if temperature variations affect the protective function of the larynx.
Main Methods:
- Four adult male Yorkshire pigs were used as subjects.
- Physiological measurements were taken under normothermic (37°C), hyperthermic (38°C–41°C), and hypothermic (36°C–34°C) conditions.
Main Results:
- Glottal closing force significantly increased with rising core body temperature.
- Glottal closing force significantly decreased with falling core body temperature.
- Findings align with neurophysiological studies in dogs, suggesting central regulation.
Conclusions:
- Altered core body temperature directly influences laryngeal glottal closing force.
- Understanding this mechanism can improve patient care for hypothermia and sedation.
- This research may enhance preventive strategies for sudden infant death syndrome related to temperature dysregulation.
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