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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Inducible clindamycin resistance among methicillin-sensitive Staphylococcus aureus infections in pediatric patients

Dror S Shouval1, Zmira Samra, Itamar Shalit

  • 1Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

The Israel Medical Association Journal : IMAJ
|November 22, 2011
PubMed
Abstract

Insights

Inducible clindamycin resistance is common in pediatric Staphylococcus aureus infections in Israel. Routine D-tests are recommended for methicillin-sensitive Staphylococcus aureus (MSSA) to detect this resistance.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Pediatrics

Background:

  • Staphylococcus aureus infections pose a significant global health burden.
  • Clindamycin is a common antibiotic for staphylococcal infections.
  • Increasing prevalence of inducible clindamycin resistance (ICR) is observed.

Purpose of the Study:

  • To determine the prevalence of ICR in pediatric methicillin-sensitive Staphylococcus aureus (MSSA) infections in Israel.
  • To evaluate the significance of ICR in clinical settings.

Main Methods:

  • Retrospective review of pediatric MSSA infection cases from January 2006 to June 2007.
  • Antibiogram testing, including the D-test for ICR.
  • Phage typing and randomly amplified polymorphic DNA analysis.

Main Results:

  • 240 MSSA isolates were analyzed, primarily from wounds and abscesses.
  • ICR was found in 26% of all MSSA isolates (62/240).
  • A specific clone of phage type 2 was associated with ICR.

Conclusions:

  • Inducible clindamycin resistance is prevalent in pediatric MSSA in Israel.
  • Routine D-testing for ICR in MSSA is recommended for appropriate treatment.
  • Understanding ICR prevalence is crucial for antibiotic stewardship.

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