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Updated: May 27, 2026

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
Published on: March 9, 2019
Gold nanoparticle induces masking of amines and some therapeutic implications
Santiswarup Singha1, Anjan K Dasgupta, Himadri Datta
1Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, India.
Abstract:
Citrate capped gold nanoparticles (GNP) are effective in masking protein amines. The extent of such masking is quantified using Fourier Transform Infra Red (FTIR) spectroscopy. A strong correlation is shown to exist between a shift of amide-II peak intensity (1600-1500 cm(-1)) caused by GNP and the number of exposed amines in a given protein. The result is validated using eight different proteins. The expected out-come of such masking is inhibition of interaction between any external ligand and such amines. The prediction is validated using a simple non-enzymatic glycation of clinically important protein like crystallin.
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