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Updated: May 27, 2026

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
14:43

Synthesis of Keratin-based Nanofiber for Biomedical Engineering

Published on: February 7, 2016

Bioactive composite for keratoprosthesis skirt.

Kaisa Laattala1, Reeta Huhtinen, Mervi Puska

  • 1Turku Clinical Biomaterials Centre-TCBC, Department of Biomaterials Science, University of Turku, Itäinen Pitkäkatu 4 B, FI-20520 Turku, Finland. kaisa.laattala@utu.fi

Journal of the Mechanical Behavior of Biomedical Materials
|November 22, 2011
PubMed
Summary

Researchers developed new bioactive glass and PMMA composites for keratoprosthesis skirts. These materials show promise for treating severe corneal damage, offering stable synthetic options for ocular surgery.

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Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Materials Engineering

Background:

  • Osteo-odonto-keratoprosthesis (OOKP) surgery requires robust synthetic skirt materials.
  • Current materials face limitations in biocompatibility and long-term stability.
  • Developing novel bioactive composites is crucial for advancing OOKP procedures.

Purpose of the Study:

  • To fabricate and characterize novel bioactive glass and polymethyl methacrylate (PMMA)-based composites for keratoprosthesis skirts.
  • To evaluate the in vitro dissolution behavior, mechanical properties, and pore formation of these composite materials.
  • To assess the suitability of these synthetic materials for use in OOKP surgery.

Main Methods:

  • Fabrication of composites using four bioactive glasses (45S5, S53P4, 1-98, FL107) and PMMA.

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Last Updated: May 27, 2026

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Published on: February 7, 2016

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  • In vitro dissolution testing in simulated aqueous humor over three and six weeks.
  • Assessment of compressive properties and surface pore formation of the composite specimens.

    • Main Results:

    • FL107-based composites exhibited slow dissolution (2.4% over 3 weeks) with restricted pore formation.
    • Bioactive glass-PMMA composites showed higher dissolution rates (12%-17%) with slight surface porosity.
    • Compressive strength decreased by 22% after six weeks of in vitro dissolution for particle-containing composites.

    Conclusions:

    • Bioactive glass-PMMA composites demonstrate potential as stable synthetic materials for keratoprosthesis skirts.
    • The dissolution characteristics and mechanical properties suggest suitability for supporting corneal regeneration and function.
    • These findings support the use of these advanced biomaterials in treating severely damaged or diseased corneas.