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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Published on: June 26, 2020

Hepatitis E virus in rabbits, Virginia, USA.

Caitlin M Cossaboom1, Laura Córdoba, Barbara A Dryman

  • 1Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0913, USA.

Emerging Infectious Diseases
|November 22, 2011
PubMed
Summary

Hepatitis E virus (HEV) was found in rabbits in Virginia. This finding suggests a potential role for rabbits in the transmission of HEV genotype 3 in the USA.

Area of Science:

  • Veterinary Virology
  • Zoonotic Disease Research
  • Public Health

Background:

  • Hepatitis E virus (HEV) is a significant human pathogen.
  • The epidemiology and animal reservoirs of HEV, particularly in the United States, require further investigation.

Purpose of the Study:

  • To investigate the presence and genetic characteristics of Hepatitis E virus in a rabbit population in Virginia, USA.

Main Methods:

  • Detection of HEV RNA in serum and fecal samples using molecular methods.
  • Serological testing for HEV antibodies.
  • Phylogenetic analysis of detected HEV sequences.

Main Results:

  • HEV RNA was detected in 16% of serum samples and 15% of fecal samples.

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  • Antibodies against HEV were found in 36% of the rabbits.
  • Sequence analysis revealed HEV strains closely related to genotype 3.

    • Conclusions:

    • Rabbits in Virginia harbor Hepatitis E virus.
    • The identified HEV strains are linked to genotype 3, suggesting a potential role in zoonotic transmission.