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Updated: May 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
[Factors influencing the bone mineral density in preterm infants]
1Department of Pediatrics, West China Second Hospital of Sichuan University, Chengdu, China.
Insights
Preterm infants show lower bone mineral density than term infants. Promoting bone development in preterm infants can be achieved through appropriate weaning times and increased outdoor activity.
Area of Science:
- Pediatric bone health research.
- Neonatal development studies.
Context:
- Preterm infants face challenges in bone mineral accretion compared to term infants.
- Early life factors significantly impact long-term skeletal development.
Purpose:
- To investigate bone mineral development in preterm infants.
- To identify key factors influencing bone mineral accrual in this population.
Summary:
- Quantitative ultrasound (Tibia quantitative ultrasound) assessed bone mineral density (speed of sound - SOS, Z scores) at 6 months corrected age.
- Preterm infants exhibited lower SOS and Z scores than term infants.
- Weaning time and daily outdoor activity duration were identified as independent factors influencing bone mineral development in preterm infants.
Impact:
- Findings suggest interventions like optimizing weaning and increasing outdoor time can enhance bone mineral development in preterm infants.
- This research provides actionable insights for improving skeletal health outcomes in vulnerable preterm populations.
Objective:
To study the bone mineral development and the factors influencing the development in preterm infants.
Methods:
Ninety preterm and 90 term infants followed up by the child health care service were randomly enrolled. Tibia quantitative ultrasound measurements were used to evaluate bone mineral density described as supersonic speed of sound (SOS) and Z scores at 6 months old (corrected gestational age for preterm infants). The factors influencing bone mineral development were investigated by questionnaire.
Results:
The SOS values and Z scores in term infants were significantly higher than those in preterm infants at 6 months old. In the preterm group, the SOS values and Z scores were significantly different in infants with different birth weights or gestational ages (P<0.05). The SOS values in preterm infants with different weaning time were significantly different. The Z scores in female preterm infants were significantly higher than that in males (P<0.05). Multiple regression analysis indicated that weaning time and daily time of outdoor activities were independent factors influencing SOS values in preterm infants.
Conclusions:
It is helpful to promote bone mineral development by an appropriate weaning time or increasing the time of outdoor activities in preterm infants.
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