Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pharyngitis

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Proposed changes to current definitions of ICHD-3 regarding headache and facial pain attributed to the disorder of the nose or paranasal sinuses.

Cephalalgia : an international journal of headache·2026

Same author

Response to the editor regarding "An eosinophil peroxidase activity assay predicts acute exacerbations in post-operative chronic rhinosinusitis".

International forum of allergy & rhinology·2024

Same author

Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis.

Journal of inflammation research·2024

Same author

An eosinophil peroxidase activity assay predicts acute exacerbations in post-operative chronic rhinosinusitis.

International forum of allergy & rhinology·2024

Same author

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.

International forum of allergy & rhinology·2023

Same author

An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis.

The Journal of allergy and clinical immunology·2023

Search research articles

Related Experiment Video

Updated: May 27, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Chronic rhinosinusitis.

Steven Marc Daines¹, Richard R Orlandi

¹Division of Otolaryngology-Head & Neck Surgery, University of Utah School of Medicine, 50 North Medical Drive, 3C120, Salt Lake City, UT 84132, USA. dainesmd@gmail.com

Facial Plastic Surgery Clinics of North America

|November 22, 2011

Summary

This article explains chronic rhinosinusitis (CRS), a condition causing nasal obstruction. Rhinoplasty surgeons need to understand CRS diagnosis and management beyond just correcting anatomical issues for effective patient treatment.

More Related Videos

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Related Experiment Videos

Last Updated: May 27, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Area of Science:

Otolaryngology
Rhinology
Surgical Anatomy

Background:

Chronic rhinosinusitis (CRS) is a prevalent condition characterized by sinonasal inflammation.
Nasal obstruction is a primary symptom, often leading patients to seek rhinoplasty.
Addressing only anatomical obstruction during rhinoplasty may not resolve CRS.

Purpose of the Study:

To define chronic rhinosinusitis (CRS).
To outline contemporary diagnostic and management principles for CRS.
To highlight practical considerations for rhinoplasty surgeons managing CRS patients.

Main Methods:

Review of current literature on CRS diagnosis and management.
Focus on the intersection of CRS and functional rhinoplasty.
Emphasis on understanding the multifactorial nature of CRS.

Main Results:

CRS is likely an umbrella diagnosis with multiple contributing factors.
Chronic sinonasal inflammation is the common endpoint of CRS.
Effective management requires understanding CRS origins, diagnosis, and treatment beyond surgical correction alone.

Conclusions:

Rhinoplasty surgeons must possess a comprehensive understanding of CRS.
Integrated management approaches are necessary for patients with CRS undergoing rhinoplasty.
Focusing solely on anatomical obstruction is insufficient for treating CRS effectively.