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Updated: May 27, 2026
07:32
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
Physiology of skin aging.
L Robert1, J Labat-Robert, A-M Robert
1Laboratoire de recherche ophtalmologique, université Paris-5, Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France. lrobert5@wanadoo.fr
Clinics in Plastic Surgery
|November 22, 2011
Summary
Skin aging involves epigenetic and post-translational changes. Fucose- and rhamnose-rich oligosaccharides (FROP and RROP) show potential in counteracting these age-related skin modifications.
Area of Science:
- Dermatology
- Biochemistry
- Cosmetic Science
Background:
- Skin aging is a significant area of research due to its physiological and social implications.
- Age-dependent modifications affect skin's cellular and extracellular matrix components.
- Key aging mechanisms occur at the post-genetic level, involving epigenetic and post-translational modifications.
Purpose of the Study:
- To review cellular and extracellular matrix aspects of skin aging.
- To explore the role of epigenetic and post-translational mechanisms in skin aging.
- To investigate the potential of fucose- and rhamnose-rich oligo- and polysaccharides (FROP and RROP) in mitigating skin aging.
Main Methods:
- Review of established mechanisms of skin aging.
- Focus on post-genetic alterations (epigenetic and post-translational).
- Analysis of the impact of FROP and RROP on skin aging pathways.
Main Results:
- Skin aging is characterized by complex post-genetic modifications.
- FROP and RROP demonstrate a capacity to counteract identified skin aging mechanisms.
- Specific cellular and extracellular matrix changes associated with aging are discussed.
Conclusions:
- Epigenetic and post-translational modifications are central to skin aging.
- FROP and RROP represent a promising class of compounds for anti-aging interventions.
- Further research into FROP and RROP can advance dermatological and cosmetic applications for skin health.
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