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Related Experiment Video

Updated: May 27, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Reactive arthritis.

¹Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, P.O. Box 340, FI-00029 HUCH, Finland. timo.hannu@helsinki.fi

Best Practice & Research. Clinical Rheumatology

|November 22, 2011

Summary

Reactive arthritis (ReA) is inflammatory arthritis following infection. While diagnosis is clinical, prolonged antibiotics may help Chlamydia-induced ReA, but evidence is lacking for other forms.

Area of Science:

Rheumatology
Infectious Diseases
Immunology

Background:

Reactive arthritis (ReA) is sterile inflammatory arthritis developing after a remote infection, typically gastrointestinal or urogenital.
Diagnosis is primarily clinical, based on acute oligoarticular arthritis of large joints appearing 2-4 weeks post-infection.
The annual incidence of ReA ranges from 0.6-27 per 100,000 population.

Purpose of the Study:

To define Reactive Arthritis (ReA) and its diagnostic considerations.
To review the role of Human Leucocyte Antigen (HLA)-B27 in ReA diagnosis.
To evaluate the efficacy of antibiotic therapy in different forms of ReA.

Main Methods:

Clinical diagnosis based on arthritis onset following infection.
Assessment of Human Leucocyte Antigen (HLA)-B27's diagnostic utility.

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Review of treatment outcomes for Chlamydia-induced ReA and other forms.

Main Results:

Diagnosis relies on clinical presentation and identifying the triggering infection; HLA-B27 is not a diagnostic tool for acute ReA.
Prolonged antibiotic treatment may benefit acute and chronic Chlamydia-induced ReA with persistent antigens.
Evidence supporting antibiotic therapy to shorten acute arthritis duration is lacking for non-Chlamydial ReA.

Conclusions:

ReA diagnosis is clinical, requiring identification of preceding infection.
Antibiotic therapy shows potential benefit in Chlamydia-induced ReA but lacks evidence for other forms.
Long-term outcomes for Chlamydia trachomatis-related ReA require further investigation.