Related Experiment Video
Updated: May 27, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
Gender differences in outcomes of a multimodal pain management program
Christoph Pieh1, Jürgen Altmeppen, Susanne Neumeier
1Department of Psychosomatic Medicine, University Regensburg, Regensburg, Germany Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany Department of Anesthesiology, Hospital Weiden, Weiden, Germany Department of Neurology, Hospital Weiden, Weiden, Germany Department of Psychosomatic Medicine, Technische Universitaet München, München, Germany.
Women experienced greater pain reduction and improved daily functioning after multimodal pain treatment compared to men. These gender differences in treatment response are clinically significant.
Area of Science:
- Pain Management
- Clinical Psychology
- Rehabilitation Medicine
Background:
- Gender disparities in pain perception and analgesic responses are established.
- Limited understanding exists regarding sex-based differences in outcomes following multimodal pain treatment.
Purpose of the Study:
- To investigate potential gender-based differences in patient outcomes after an intensive multimodal pain treatment program.
- To determine if men and women respond differently to comprehensive pain rehabilitation.
Main Methods:
- A cohort of 496 patients (254 women) completed a daily outpatient multimodal pain program (117.5 hours total therapy).
- Pretreatment assessments included pain intensity (Numeric Rating Scale), pain-related disability, pain duration, chronicity, age, and psychiatric comorbidities.
- Outcomes were analyzed for changes in pain and disability, comparing male and female participants.
Main Results:
- Overall, average pain decreased by -1.54 (ES .911), with significant improvements in pain-related disability.
- Women showed a greater reduction in pain (-1.83, ES 1.045) and disability (ES .694) compared to men (-1.23, ES .758; ES .436).
- These gender differences were independent of pain duration, medication, comorbidities, or disability pension status.
Conclusions:
- Significant gender differences exist in the response to intensive multimodal pain treatment.
- Women appear to benefit more from such programs in terms of pain reduction and functional improvement.
- These findings highlight the clinical relevance of considering gender in pain management strategies.
