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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Published on: November 14, 2017

Brain connectivity in psychiatric imaging genetics.

Heike Tost1, Edda Bilek, Andreas Meyer-Lindenberg

  • 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Neuroimage
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

Imaging genetics reveals how genetic variants influence brain connectivity, offering insights into mental illness susceptibility. This field uses advanced neuroimaging to understand neural mechanisms underlying genetic risk for psychiatric disorders.

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Area of Science:

  • Neuroimaging
  • Genetics
  • Psychiatric Disorders

Background:

  • Imaging genetics has become a key neuroimaging discipline over the last decade.
  • Neural mechanisms mediating genetic risk for mental disorders are increasingly understood.
  • Intermediate connectivity phenotypes are gaining popularity in research.

Purpose of the Study:

  • To provide an overview of scientific methods and evidence linking neural network organization to genetic susceptibility for mental illness.
  • To focus on the impact of candidate genes and genome-wide supported risk variants on brain structure and function.

Main Methods:

  • Review of existing scientific literature and research findings.
  • Analysis of neuroimaging data (brain structure and function).
  • Examination of genetic variants (candidate genes and genome-wide supported variants).

Main Results:

  • Identification of neural systems mechanisms that mediate genetic risk for mental disorders.
  • Evidence linking neural network organization indices to genetic susceptibility.
  • Demonstration of effects of genetic variants on brain structure and function.

Conclusions:

  • Imaging genetics is a powerful tool for understanding the genetic basis of mental illness.
  • Neural connectivity phenotypes are crucial for mediating genetic risk.
  • Further research can elucidate the complex interplay between genes, brain, and mental health.