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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Stem cell technology for drug discovery and development.

Lilian A Hook1

  • 1Plasticell Limited, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, United Kingdom. lilian@plasticell.co.uk

Drug Discovery Today
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

Stem cells offer revolutionary potential for drug discovery by providing physiologically relevant cells. Novel differentiation technologies are key to overcoming current challenges and enabling widespread pharmaceutical adoption.

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Area of Science:

  • Biotechnology
  • Drug Discovery
  • Stem Cell Research

Background:

  • Stem cells possess the potential to transform drug discovery from target identification to toxicology.
  • Their capacity for generating large quantities of physiologically relevant cells makes them superior to current methods.
  • Current limitations include the difficulty in consistently directing stem cell differentiation into pure cell populations.

Purpose of the Study:

  • To review the current applications of stem cells in drug discovery.
  • To explore how novel stem cell differentiation technologies can enhance their use.
  • To facilitate the broader adoption of stem cell technology within the pharmaceutical industry.

Main Methods:

  • Literature review of stem cell applications in drug discovery.
  • Analysis of emerging technologies in stem cell differentiation.
  • Discussion of strategies for overcoming adoption barriers in the pharmaceutical sector.

Main Results:

  • Stem cells are already utilized in various stages of drug discovery, offering advantages over traditional methods.
  • Advancements in directed differentiation are crucial for generating specific, pure cell populations.
  • Addressing reproducibility and cost-effectiveness is essential for industry-wide implementation.

Conclusions:

  • Stem cell technology holds significant promise for revolutionizing drug discovery.
  • Overcoming differentiation challenges through new technologies is vital for realizing this potential.
  • Widespread adoption by the pharmaceutical industry is achievable with further technological development and validation.