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High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
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Screening of protein crystallization trials by second order nonlinear optical imaging of chiral crystals (SONICC)

Levi M Haupert1, Garth J Simpson

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47904, United States.

Methods (San Diego, Calif.)
|November 22, 2011
PubMed

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In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...