Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress management reduces severe depression and anxiety symptoms in adults with cystic fibrosis: Results from the coping and learning to manage stress (CALM) intervention.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

The Human Cost of Respiratory Care: Professional Quality of Life and Burnout Across Multidisciplinary Cystic Fibrosis Teams.

Chest·2026
Same author

Advancing Mental Healthcare for Individuals With Cystic Fibrosis in Low- and Middle-Income Countries.

Pediatric pulmonology·2026
Same author

Integrating cognitive behavioral therapy into specialty care for adolescents with cystic fibrosis: a feasibility trial.

Journal of pediatric psychology·2026
Same author

Stakeholder Priorities for Cystic Fibrosis Mental Health Research: A Community and Provider Survey.

Pediatric pulmonology·2026
Same author

Core outcome domains for <i>Mycobacterium avium</i> complex pulmonary disease: a MACCOR study.

ERJ open research·2025
Same journal

X-chromosomal genetic variants and haplotype analysis in male cerebral palsy patients: insights into genetic susceptibility and sex-specific risk.

Journal of neurodevelopmental disorders·2026
Same journal

Exploring the relationship between auditory processing characteristics and cognition in preschool children with developmental language disorder based on fNIRS.

Journal of neurodevelopmental disorders·2026
Same journal

DRP1 mutations associated with EMPF1 encephalopathy perturb the transcriptional profile and maturation of cortical neurons.

Journal of neurodevelopmental disorders·2026
Same journal

Epilepsy in autism spectrum disorder: examining prevalence and associated factors in a large cross-sectional study.

Journal of neurodevelopmental disorders·2026
Same journal

The prevalence of neurodevelopmental disorders in Smith-Magenis Syndrome: a PRISMA compliant systematic review.

Journal of neurodevelopmental disorders·2026
Same journal

Early developmental trajectories associated with different styles and intensities of ESDM-based community intervention.

Journal of neurodevelopmental disorders·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

Long-term Time Lapse Imaging of Mouse Cochlear Explants
10:43

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Published on: November 2, 2014

Language development after cochlear implantation: an epigenetic model.

Timothy M Markman1, Alexandra L Quittner, Laurie S Eisenberg

  • 1Johns Hopkins School of Medicine, Baltimore, MD, USA.

Journal of Neurodevelopmental Disorders
|November 22, 2011
PubMed
Summary
This summary is machine-generated.

Early cochlear implantation (CI) significantly benefits spoken language development in congenitally deaf children. Parent-child interactions also play a crucial role, with their impact varying by implantation age.

More Related Videos

The Miniature Pig: A Large Animal Model for Cochlear Implant Research
06:16

The Miniature Pig: A Large Animal Model for Cochlear Implant Research

Published on: July 28, 2022

Related Experiment Videos

Last Updated: May 27, 2026

Long-term Time Lapse Imaging of Mouse Cochlear Explants
10:43

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Published on: November 2, 2014

The Miniature Pig: A Large Animal Model for Cochlear Implant Research
06:16

The Miniature Pig: A Large Animal Model for Cochlear Implant Research

Published on: July 28, 2022

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Dynamic gene expression and epigenetics influence spoken language acquisition.
  • Children with severe to profound sensorineural hearing loss face challenges in auditory-phonologic input during critical developmental periods.

Purpose of the Study:

  • To evaluate factors influencing spoken language emergence after cochlear implantation in congenitally deaf children.
  • To examine the impact of age at implantation and environmental variables on language development.

Main Methods:

  • Longitudinal trial analysis of the Childhood Development after Cochlear Implantation (CDaCI) study.
  • Assessment of cochlear implantation outcomes in 116 congenitally deaf participants.

Main Results:

  • Significant advantages in spoken language learning were observed for children implanted before 18 months of age.
  • Age at implantation is a strong predictor of spoken language performance.
  • Parent-child interactions significantly correlate with language development, with their influence moderated by implantation age.

Conclusions:

  • Early cochlear implantation is critical for optimizing spoken language outcomes in deaf children.
  • An epigenetic framework helps understand how dynamic gene expression and environmental factors interact to shape language development.
  • Understanding these interactions can inform targeted interventions to improve language acquisition post-implantation.