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To sprout or to split? VEGF, Notch and vascular morphogenesis.

Roberto Gianni-Barrera1, Marianna Trani, Silvia Reginato

  • 1Cell and Gene Therapy, Department of Biomedicine, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland. giannibarrerar@uhbs.ch

Biochemical Society Transactions
|November 23, 2011
PubMed
Summary

Therapeutic angiogenesis aims to treat vascular disease by promoting new blood vessel growth. This review explores how vascular endothelial growth factor-A (VEGF) and Notch signaling regulate sprouting angiogenesis and contrasts it with intussusception.

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