Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart
Brian O'Rourke1, Jennifer E Van Eyk, D Brian Foster
1Department of Medicine, Division of Cardiology, The Johns Hopkins University, Baltimore, MD 21205-2195, USA. bor@jhmi.edu
Congestive Heart Failure (Greenwich, Conn.)
|November 23, 2011
Summary
Mitochondrial protein phosphorylation, regulated by kinases and phosphatases, is increasingly discovered using mass spectrometry. Its role in cardiac disease warrants further investigation.
Area of Science:
- Mitochondrial biology
- Molecular cell biology
- Biochemistry
Background:
- Mitochondrial protein phosphorylation is a known regulatory mechanism.
- Novel phosphorylation sites are being discovered via mass spectrometry.
- Kinases and phosphatases are implicated in mitochondrial regulation.
Purpose of the Study:
- To review phosphorylation as a mitochondrial regulatory strategy.
- To explore the role of mitochondrial phosphorylation in cardiac pathophysiology.
- To highlight unanswered questions regarding mitochondrial phosphorylation.
Main Methods:
- Literature review of mitochondrial phosphorylation.
- Discussion of mass spectrometry-based discoveries.
- Analysis of kinase and phosphatase roles in mitochondria.
Main Results:
- Evidence suggests kinases and phosphatases are present in various mitochondrial compartments.
- Numerous novel phosphorylation sites have been identified.
- The functional relevance and regulation of these sites are still under investigation.
Conclusions:
- Phosphorylation is a key regulatory strategy in mitochondria.
- Mitochondrial phosphorylation may play a role in cardiac hypertrophy and failure.
- Further research is needed to elucidate the precise mechanisms and functions.
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