Related Experiment Video
Updated: May 27, 2026
07:30
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
[What's new in immune-mediated neuropathies?]
1Service de neurologie, CHU Limoges, 2, avenue Martin-Luther King, 87042 Limoges cedex, France. laurent.magy@unilim.fr
Revue Neurologique
|November 23, 2011
Summary
Recent research in immune-mediated neuropathies covers diagnostic criteria, pain, and immunological markers. New guidelines for nerve biopsy in peripheral neuropathy were also published in 2010.
Area of Science:
- Neurology
- Immunology
- Pathology
Context:
- The year 2010 saw significant publications on immune-mediated neuropathies.
- Research covered diagnostic criteria, clinical presentations, pain factors, and immunological markers.
- Guidelines for nerve biopsy in peripheral neuropathy were updated.
Purpose:
- To provide a comprehensive summary of recent discoveries in immune-mediated neuropathies.
- To consolidate key findings and advancements from 2010.
Summary:
- Key areas of focus included diagnostic standards and diverse clinical forms of these neuropathies.
- Investigated risk factors for pain and advancements in clinical evaluation methods.
- Highlighted the continued relevance and updated guidelines for nerve biopsy procedures.
Impact:
- Offers a consolidated overview for clinicians and researchers in the field.
- Facilitates understanding of the latest developments in diagnosing and managing immune-mediated neuropathies.
- Underscores the importance of updated guidelines for diagnostic procedures.
Related Concept Videos
01:22Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...