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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Caudal image contrast inversion in MPRAGE at 7 Tesla: problem and solution.

Karsten H Wrede1, Sören Johst, Philipp Dammann

  • 1Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, UNESCO World Cultural Heritage Zollverein, Leitstand Kokerei Zollverein, Germany. karsten.wrede@uk-essen.de

Academic Radiology
|November 23, 2011
PubMed
Summary

A modified magnetization preparation pulse in the 7 Tesla MPRAGE sequence significantly reduces caudal image contrast inversion, improving MRI quality for clinical applications.

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Area of Science:

  • Radiology
  • Magnetic Resonance Imaging
  • Neuroimaging

Background:

  • The standard Magnetization-Prepared Rapid Acquisition Gradient-Echo (MPRAGE) sequence at 7 Tesla (T) often exhibits caudal image contrast inversion.
  • This artifact limits the clinical utility of 7T MPRAGE scans.

Purpose of the Study:

  • To identify the technical cause of caudal image contrast inversion in 7T MPRAGE.
  • To present and evaluate a practical solution to mitigate this artifact.

Main Methods:

  • 71 subjects were scanned using a 7T MRI system with a 32-channel head coil.
  • Standard MPRAGE and a modified MPRAGE sequence utilizing an adiabatic wideband uniform rate smooth truncation pulse for magnetization preparation were compared.
  • Image contrast homogeneity and inversion were assessed by two neuroradiologists.

Main Results:

  • Caudal image contrast inversion occurred in 42.2% of standard MPRAGE acquisitions.
  • The modified sequence with the adiabatic pulse reduced inversion to 6.7%.
  • A chi-squared test confirmed a statistically significant difference (P < .001) between the sequences.

Conclusions:

  • Magnetization preparation with an adiabatic wideband uniform rate smooth truncation pulse effectively reduces caudal image contrast inversion in 7T MPRAGE.
  • This technical improvement enhances signal homogeneity and clinical applicability of 7T MRI.