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Bullous dermatosis associated with vancomycin extravasation.
Nicole M Bohm1, Jeffrey G Wong2
1Department of Pharmacy Services and Division of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, South Carolina.
The American Journal of the Medical Sciences
|November 23, 2011
Summary
Vancomycin extravasation can cause skin reactions. A patient developed a localized bullous eruption mimicking linear IgA bullous dermatosis after vancomycin extravasation, a novel finding.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Cutaneous side effects are known complications of systemic vancomycin therapy.
- These reactions are typically immunological, triggered by systemic drug administration.
- Drug extravasation can lead to diverse soft tissue reactions based on drug properties and local effects.
Observation:
- A case of vancomycin extravasation is presented.
- The extravasation resulted in a localized bullous eruption.
- The eruption clinically resembled linear IgA bullous dermatosis.
Findings:
- Vancomycin extravasation can induce a localized bullous eruption.
- This specific presentation mimics linear IgA bullous dermatosis.
- This phenomenon has not been previously documented in medical literature.
Implications:
- Highlights a new potential cutaneous manifestation of vancomycin extravasation.
- Expands the differential diagnosis for bullous eruptions in patients receiving vancomycin.
- Suggests the need for careful monitoring of extravasation sites during vancomycin therapy.
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