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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...

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Updated: May 27, 2026

Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy
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Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy

Published on: May 18, 2011

Developments in and practical guidelines for tip-enhanced Raman spectroscopy.

Johannes Stadler1, Thomas Schmid, Renato Zenobi

  • 1ETH Zurich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, HCI E 329, 8093 Zurich, Switzerland.

Nanoscale
|November 23, 2011
PubMed
Summary
This summary is machine-generated.

This review covers tip-enhanced Raman spectroscopy (TERS) advancements, instruments, and applications. It addresses TERS imaging challenges and offers guidelines for new researchers to optimize setups for

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Area of Science:

  • Nanoscale spectroscopy and microscopy
  • Surface science and materials characterization
  • Advanced optical techniques

Background:

  • Tip-enhanced Raman spectroscopy (TERS) offers unparalleled nanoscale chemical sensitivity.
  • Existing reviews lack comprehensive coverage of TERS instrumentation and practical implementation.
  • The transition of TERS from point spectroscopy to a robust imaging technique requires further investigation.

Purpose of the Study:

  • To provide a state-of-the-art overview of tip-enhanced Raman spectroscopy (TERS).
  • To detail various TERS instrument types, their pros, cons, and capabilities.
  • To discuss challenges in TERS, including background signals and imaging progression.

Main Methods:

  • Comprehensive literature review of recent TERS developments and applications.
  • Comparative analysis of different TERS instrument designs and their performance.
  • Discussion of sample preparation and data interpretation in TERS experiments.

Main Results:

  • Detailed examination of current TERS instrumentation, highlighting advantages and limitations.
  • Exploration of TERS applications across diverse sample types.
  • Identification of key challenges hindering TERS widespread adoption, such as background noise and reproducibility.

Conclusions:

  • TERS is a powerful technique with significant potential for nanoscale chemical analysis.
  • Addressing background signals and improving imaging capabilities are crucial for TERS advancement.
  • A user guideline and community-driven solutions are needed to facilitate 'push-button' TERS operation.