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Related Experiment Video

Updated: May 27, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

IgA anti-p200 pemphigoid.

Katarzyna Wozniak1, Takashi Hashimoto, Shunpei Fukuda

  • 1Department of Dermatology, Medical University of Warsaw, Koszykowa 82a St, 02-008 Warszawa, Poland. kwozniak@wum.edu.pl

Archives of Dermatology
|November 23, 2011
PubMed
Summary

This study details the first reported case of anti-p200 pemphigoid with IgA antibodies, presenting unique clinical features. The findings advance understanding of this rare autoimmune blistering disease.

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Area of Science:

  • Dermatology
  • Immunology
  • Autoimmune Diseases

Background:

  • Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disorder.
  • It can clinically mimic other blistering conditions like bullous pemphigoid.
  • Characterized by IgG antibodies against a 200 kDa basement membrane zone protein.

Observation:

  • Presents the first known case of anti-p200 pemphigoid associated with IgA antibodies.
  • Clinical presentation resembled pemphigus herpetiformis or dermatitis herpetiformis on traumatized skin.
  • Histopathology revealed dermal-epidermal separation and dermal papillary microabscesses.

Findings:

  • Direct immunofluorescence showed linear in vivo-bound IgA at the basement membrane zone.
  • IgA antibodies were localized above collagen type IV and colocalized with laminin 332.

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Published on: October 12, 2012

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Last Updated: May 27, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

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Published on: June 17, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

  • Circulating IgA antibodies targeted the 200 kDa antigen (laminin γ1) in Western immunoblot analysis.

    • Implications:

    • This case expands the immunopathological criteria for anti-p200 pemphigoid.
    • Highlights the diagnostic importance of considering IgA antibodies in atypical presentations.
    • Contributes to understanding the diverse immunological targets in pemphigoid variants.