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Updated: May 27, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Roles of IL-8 in ocular inflammations: a review
Hassan Ghasemi1, Tooba Ghazanfari, Roya Yaraee
1Immunoregulation Research Center, Shahed University, Tehran, Iran. ghasemi518@yahoo.com
Introduction:
This review presents the current in vitro and in vivo animal and human research on the roles of IL-8 in ocular inflammatory diseases.
Materials And Methods:
Data sources were a literature review using Pub Med, Medline, and ISI databases (from 1990 to 2011). Search items included interleukine-8 (IL-8), CXCL8, chemokines, cytokines, alone or in combination with the, serum, aqueous, vitreous, eye, ocular, ocular tissues, ophthalmic, and review.
Results:
IL-8 may be involved in primary or secondary ocular inflammations. Ocular effects of IL-8 differ based on the source of the secretion and site of the action. The most important effects of IL-8 in the eyes are angiogenic activities and induction of ocular inflammation.
Conclusion:
IL-8 plays important roles in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. Anti-IL-8 targeted immunotherapy has been introduced as an important treatment modality, provided that IL-8 signal blocking takes place in desired areas and tissues.
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