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Updated: May 27, 2026
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Long-term results of therapy with mycophenolate mofetil in ocular mucous membrane pemphigoid
Deshka Doycheva1, Christoph Deuter, Gunnar Blumenstock
1Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany. deshka.doycheva@med.uni-tuebingen.de
Purpose:
To assess the long-term efficacy and tolerability of mycophenolate mofetil (MMF) in the therapy of ocular mucous membrane pemphigoid (OcMMP).
Methods:
Ten patients (19 eyes) with OcMMP treated with MMF, who had a follow-up of at least 4 years, were retrospectively analyzed. Main outcome measures were inflammatory control, progression of cicatrization, and side effects.
Results:
Control of inflammation was achieved in 11 eyes (58%) of 6 patients (rate: 0.11/PY). Mild inflammatory activity was observed in 8 eyes (42%) of 4 patients (rate: 0.07/PY). Progression of conjunctival cicatrization was prevented in 47% (9/19) of the eyes. Mild progression of cicatrization was found in 42% (8/19) of the eyes. Conjunctival cicatrization had progressed to stage IV in 1 patient (11%). Treatment-related side effects occurred in 7 patients (rate: 0.12/PY).
Conclusion:
MMF is an effective agent for treatment of OcMMP. However, the drug cannot always prevent disease progression.