Related Experiment Video

Updated: May 27, 2026

A Murine Model of Pressure Overload-Induced Right Ventricular Hypertrophy and Failure by Pulmonary Trunk Banding
04:49

A Murine Model of Pressure Overload-Induced Right Ventricular Hypertrophy and Failure by Pulmonary Trunk Banding

Published on: June 14, 2024

Pressure overload

Edward D Frohlich1, Dinko Susic

  • 1Hypertension Research Laboratory, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA. efrohlich@ochsner.org

Heart Failure Clinics
|November 24, 2011
PubMed

Insights

Pressure overload causes ventricular hypertrophy, a compensatory response that can lead to heart failure. This review details the molecular mechanisms behind maladaptive structural changes in the heart.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Pathophysiology

Background:

  • Elevated pressure in the heart leads to ventricular hypertrophy.
  • Ventricular hypertrophy is an adaptive response to increased cardiac wall stress.

Purpose of the Study:

  • To review the cardiac consequences of pressure overload.
  • To emphasize the molecular mechanisms driving hypertrophy and maladaptive changes.

Main Methods:

  • Literature review of studies on pressure overload and cardiac remodeling.
  • Analysis of molecular pathways involved in ventricular hypertrophy.

Main Results:

  • Ventricular hypertrophy, while initially compensatory, can lead to ventricular dysfunction.
  • Maladaptive structural changes driven by molecular mechanisms contribute to heart failure.

Conclusions:

  • Understanding the molecular basis of hypertrophy is crucial for preventing heart failure.
  • Targeting these mechanisms may prevent adverse cardiac events.

More Related Videos

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study09:24

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study

Published on: October 12, 2011

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Related Concept Videos

Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.
Fluid Pressure01:14

Fluid Pressure

In mechanical engineering, fluid pressure plays a critical role in designing systems that utilize liquid flow, such as hydraulic systems, pumps, and valves. When designing these systems, engineers must ensure they can withstand the forces created by fluid pressure to avoid damage or failure.
According to Pascal's law, a fluid at rest will generate equal pressure in all directions. This pressure is measured as a force per unit area, and its magnitude depends on the fluid's specific weight or...
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...