Related Experiment Videos
Acuity card assessment of visual function in the cryotherapy for retinopathy of prematurity trial
V Dobson1, G E Quinn, A W Biglan
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15260.
Insights
The Acuity Card procedure successfully measured visual function in premature infants treated for retinopathy. This method demonstrated high testability and reliable results in the Cryotherapy for Retinopathy of Prematurity trial.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Clinical Trials
Background:
- The Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) initially focused on retinal anatomy.
- Assessing visual function is crucial for understanding treatment outcomes in retinopathy of prematurity.
Purpose of the Study:
- To describe the integration and evaluation of the Acuity Card procedure for visual function assessment in the CRYO-ROP study.
- To determine the feasibility and reliability of the Acuity Card procedure in infants treated for retinopathy of prematurity.
Main Methods:
- The Acuity Card procedure was added to the CRYO-ROP study protocol.
- Trained testers measured monocular grating acuity in randomized and natural-history infants.
- Testing was conducted one year postcryotherapy or one year postterm.
Main Results:
- The Acuity Card procedure achieved a high testability rate, with data obtained in 95% of attempted infant assessments.
- Interobserver test-retest reliability was strong, with agreement within one octave or better in most cases.
- The procedure proved successful in assessing visual function in this infant population.
Conclusions:
- The Acuity Card procedure is a viable and effective method for assessing visual function in infants participating in the CRYO-ROP trial.
- This addition enhanced the CRYO-ROP study by providing crucial visual function data alongside anatomical outcomes.
Abstract:
The primary outcome measure of the effectiveness of cryotherapy in the original design of the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) was the anatomic status of the retina, as documented by fundus photography 3 months and 12 months after infants had received treatment. The authors describe the addition of a measurement of visual function, the Acuity Card procedure, to the CRYO-ROP study. After training, four visual-acuity testers attempted to measure monocular grating acuity in all randomized infants and approximately one fourth of the natural-history infants in the study, tested at 1 year postcryotherapy or 1 year postterm. In 95% of infants on whom testing was attempted, monocular acuity values from each eye were obtained. Interobserver test-retest results on 25 eyes of 13 randomized infants agreed to within one octave or better in all but one of the eyes. The high testability rate and good interobserver agreement suggest that the Acuity Card procedure has been a successful method of assessing visual function in the CRYO-ROP study.