Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

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Andrew Fretzayas1, Olga Liapi, Anna Papadopoulou

  • 1Third Department of Pediatrics, "Attikon" General University Hospital, 1 Rimini Street, Haidari, 124 62 Athens, Greece.

Case Reports in Medicine
|November 24, 2011
PubMed

Insights

Ceftriaxone antibiotic can cause temporary gallstones (pseudolithiasis) in children. This study suggests a link between this side effect and a specific UGT1A1 gene variation in affected children.

Area of Science:

  • Pharmacology
  • Genetics
  • Pediatrics

Background:

  • Ceftriaxone is a third-generation cephalosporin antibiotic.
  • Transient cholelithiasis, or pseudolithiasis, is a known adverse effect of ceftriaxone in children.
  • The exact mechanism causing ceftriaxone-induced pseudolithiasis remains unclear.

Observation:

  • This report details three pediatric cases of ceftriaxone-induced pseudolithiasis.
  • All three children were identified as carriers of the A(TA)7TAA polymorphism in the UGT1A1 gene.

Findings:

  • The co-occurrence of ceftriaxone-induced pseudolithiasis and the UGT1A1 A(TA)7TAA polymorphism was observed in these cases.
  • This suggests a potential genetic predisposition to developing pseudolithiasis when treated with ceftriaxone.

Implications:

  • The UGT1A1 gene polymorphism may play a role in the pathogenesis of ceftriaxone-induced pseudolithiasis.
  • Further research is warranted to confirm this association and elucidate the underlying molecular mechanisms.
  • This finding could inform risk assessment and patient management for ceftriaxone therapy in pediatric populations.

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