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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 27, 2026

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
07:29

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Review of bone substitutes.

Landon S Pryor, Earl Gage, Claude-Jean Langevin

    Craniomaxillofacial Trauma & Reconstruction
    |November 24, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This review covers bone substitutes for craniofacial reconstruction, detailing ideal characteristics and common materials like calcium phosphate and bioactive glass. Future research focuses on tissue engineering and implant bioactivity.

    Keywords:
    Bone substitutesbiomaterialscalcium phosphate cementshydroxyapatitepolymethylmethacrylateporous polyethylene

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    Biological Compatibility Profile on Biomaterials for Bone Regeneration
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    Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
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    Biological Compatibility Profile on Biomaterials for Bone Regeneration
    10:28

    Biological Compatibility Profile on Biomaterials for Bone Regeneration

    Published on: November 16, 2018

    Area of Science:

    • Biomaterials Science
    • Regenerative Medicine
    • Craniofacial Surgery

    Background:

    • Bone substitutes are essential in craniofacial surgery and trauma reconstruction.
    • The selection of appropriate biomaterials is critical for successful outcomes.
    • Advancements in materials science have led to a diverse range of bone substitute options.

    Purpose of the Study:

    • To review the historical development of bone substitutes.
    • To define the ideal characteristics of bone substitutes for craniofacial applications.
    • To provide an in-depth discussion of commonly used bone substitute materials.

    Main Methods:

    • Literature review of historical and current bone substitute research.
    • Analysis of material properties and clinical applications.
    • Discussion of emerging trends in bone substitute technology.

    Main Results:

    • Identified key historical milestones in bone substitute development.
    • Outlined essential properties for effective craniofacial bone substitutes.
    • Detailed the properties and applications of calcium phosphate, hydroxyapatite, bioactive glass, and polymers.

    Conclusions:

    • Bone substitutes play a vital role in modern craniofacial reconstruction.
    • Material selection should be guided by specific clinical needs and ideal characteristics.
    • Future directions emphasize tissue engineering and enhanced bioactivity for improved bone regeneration.