Related Experiment Video

Updated: May 27, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Absence of cerebral microbleeds predicts reversion of vascular 'cognitive impairment no dementia' in stroke

Wai Kwong Tang1, Yang-Kun Chen, Jin-Yan Lu

  • 1Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, SAR.

International Journal of Stroke : Official Journal of the International Stroke Society
|November 25, 2011
PubMed
Abstract

Insights

The absence of cerebral microbleeds may predict cognitive recovery in stroke patients. This finding suggests a potential link between microbleeds and the reversibility of cognitive impairment after stroke.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • Cerebral microbleeds are implicated in stroke-related cognitive deficits.
  • Cognitive impairment no dementia (CIND) is prevalent post-stroke and can be reversible.

Purpose of the Study:

  • To investigate the association between cerebral microbleeds and the reversion from CIND to normal cognition in stroke survivors.

Main Methods:

  • 328 Chinese acute ischemic stroke patients were assessed for CIND at 3 and 15 months post-stroke.
  • Neuropsychological testing identified patients who reverted from CIND to normal cognition (reverters).

Main Results:

  • Absence of cerebral microbleeds was an independent predictor of cognitive reversion (OR 4.3).
  • Younger age, less hypertension, and smaller white matter hyperintensity volumes were associated with reversion.
  • Absence of deep microbleeds predicted language domain reversion; absence of lobar microbleeds predicted visuomotor speed domain reversion.

Conclusions:

  • Cerebral microbleed absence may enhance the likelihood of reversible cognitive impairment post-stroke.
  • The underlying mechanisms linking microbleeds to cognitive reversibility require further investigation.

More Related Videos

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...