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Renal Tubule and Collecting Duct

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Related Experiment Video

Updated: May 27, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Renal cell carcinoma.

Paul Cairns1

  • 1Departments of Surgical Oncology and Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA. p_cairns@fccc.edu

Cancer Biomarkers : Section a of Disease Markers
|November 25, 2011
PubMed
Summary
This summary is machine-generated.

Renal Cell Carcinoma (RCC) is a deadly cancer, but early detection improves survival. Research into its molecular basis and molecular markers is crucial for better early detection and prognosis of this kidney cancer.

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Last Updated: May 27, 2026

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11:27

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Area of Science:

  • Oncology
  • Genitourinary Cancer Research
  • Molecular Biology

Background:

  • Renal Cell Carcinoma (RCC) has a high mortality rate and rising incidence.
  • Early-stage RCC is curable with surgery, but recurrence remains a risk.
  • Active surveillance is an option for small renal masses due to incidental detection and an aging population.

Purpose of the Study:

  • To review early-stage Renal Cell Carcinoma (RCC) confined within the renal capsule.
  • To highlight the importance of understanding the molecular basis of RCC.
  • To emphasize the potential of molecular markers for early detection and prognosis.

Main Methods:

  • Review of current literature on RCC genetics, biology, and behavior.
  • Analysis of insights from inherited RCC syndromes and sporadic RCC.
  • Discussion of global omics studies (copy number, sequencing, expression, methylation).

Main Results:

  • RCC is a heterogeneous cancer with diverse histological types, genetics, and behaviors.
  • Genes predisposing to inherited RCC syndromes offer insights into sporadic RCC.
  • Omics technologies are vital for elucidating oncogenes and tumor suppressor genes in RCC.

Conclusions:

  • Further research into molecular markers is needed for early RCC detection and prognosis.
  • Understanding the molecular underpinnings of RCC is key to improving patient outcomes.
  • Continued investigation into RCC heterogeneity and behavior is essential for effective management.