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Updated: Aug 1, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
Published on: May 14, 2012
[Enteropathy-associated T-cell lymphoma: a diagnostic challenge]
Victoria Busto Bea1, Laura Crespo Pérez, Miguel Ángel Rodríguez-Gandía
1Servicio de Aparato Digestivo, Hospital Universitario Ramón y Cajal, Madrid, España. victoriabusto@live.com
Abstract:
Diagnosis of refractory celiac disease (CD) is based on exclusion of other disorders, persistence of malabsorptive symptoms and villous atrophy, despite a strict gluten-free diet for at least 6-12 months. Detection of alterations in the intraepithelial lymphocyte population is crucial for diagnosis. A subgroup of patients with refractory CD may develop severe complications such as enteropathy-associated T cell lymphoma (EATL). We present the case of a patient with longstanding silent CD who developed EALT, highlighting the challenge posed by the diagnosis and treatment of this entity.

