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Synthesis and antibacterial activity of C-2 alkenylthio-carbapenem derivatives
D F Corbett1, S Coulton, D J Knowles
1Beecham Pharmaceuticals, Betchworth, Surrey, UK.
The Journal of Antibiotics
|September 1, 1990
Abstract:
A number of C-2 aminoalkenylthio-carbapenem derivatives possessing both the (5R,6R, 8S)- and the (5R,6S,8R)-stereochemistries have been prepared from the olivanic acids MM 22382 and MM 22383, respectively. Certain members of this new class of compounds displayed potent, broad spectrum antibacterial activity as well as improved stability to human kidney homogenate.