Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites
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J M Schaeffer1, E G Frazier, A R Bergstrom
1Department of Biochemical Parasitology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
The Journal of Antibiotics
|September 1, 1990
Abstract:
Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.