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Endoplasmic reticulum stress enhances γ-secretase activity

Kazunori Ohta1, Akihito Mizuno, Shimo Li

  • 1Department of Neurobiology, Gifu University Graduate School of Medicine, Gifu, Japan.

Biochemical and Biophysical Research Communications
|November 26, 2011
PubMed
Summary

Endoplasmic reticulum (ER) stress increases amyloid-beta (Aβ) secretion in Alzheimer's disease (AD) by inducing presenilin-1. This process, linked to obesity and diabetes, is inhibited by quercetin, suggesting a novel therapeutic target for AD.

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