Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypertrophic Olivary Degeneration Following Brainstem Hemorrhage in a Patient with Tremor: A Case Report with Serial MRI Follow-Up.

Journal of clinical medicine·2026
Same author

Comparison of Femoral Neck and Lumbar Spine BMD as Correlates of Atlantoaxial Subluxation in Rheumatoid Arthritis.

Journal of Korean Neurosurgical Society·2026
Same author

Sagittal Alignment and Segmental Mobility After Cervical Intradural Extramedullary Tumor Surgery: A Comparative Analysis of Unilateral Hemilaminectomy and Laminotomy with Laminoplasty.

Journal of clinical medicine·2026
Same author

Machine Learning Prediction of Prevertebral Soft Tissue Swelling after Single-Level Anterior Cervical Surgery : A Proof-of-Concept Study.

Journal of Korean Neurosurgical Society·2026
Same author

Differential Effects of the COVID-19 Pandemic on Surgical Utilization by Procedure Type: Analysis of Korean National Health Insurance Data [2017-2021].

Journal of clinical medicine·2026
Same author

Comparative evaluation of generative artificial intelligence models for synthetic knee radiograph augmentation in clinical research.

BMC medical imaging·2026

Related Experiment Video

Updated: May 27, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
04:12

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Lhermitte-Duclos disease presenting with hydrocephalus.

Mun Sul Yang1, Choong Hyun Kim, Jin Hwan Cheong

  • 1Department of Neurosurgery, Hanyang University Guri Hospital, Guri, South Korea.

Acta Neurochirurgica. Supplement
|November 26, 2011
PubMed
Summary

Lhermitte-Duclos disease (LDD) is a rare cerebellar disorder. This case highlights LDD causing obstructive hydrocephalus, managed with surgery and potential shunting for symptom relief.

Related Experiment Videos

Last Updated: May 27, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
04:12

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Area of Science:

  • Neurology
  • Neurosurgery
  • Pathology

Background:

  • Lhermitte-Duclos disease (LDD) is a rare cerebellar disorder causing cerebellar enlargement.
  • Clinical symptoms often stem from mass effect and obstructive hydrocephalus.

Observation:

  • A 68-year-old woman presented with vertigo, vomiting, and headache.
  • Imaging revealed hydrocephalus and a cerebellar mass compressing the fourth ventricle.

Findings:

  • Subtotal removal of the cerebellar mass was performed.
  • Pathology confirmed dysplastic gangliocytoma with abnormal ganglionic neurons and an enlarged molecular layer.

Implications:

  • Surgical cytoreduction can alleviate mass effect symptoms in LDD.
  • Postoperative swelling may worsen hydrocephalus, necessitating shunting as a subsequent management step.