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Related Experiment Video

Updated: May 27, 2026

Quantification of Atherosclerosis in Mice
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Published on: June 12, 2019

Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice.

Camille M Balarini1, Mariana Zt Oliveira, Thiago Mc Pereira

  • 1Laboratory of Transgenes and Cardiovascular Control, Physiological Sciences Graduate Program, Federal University of Espirito Santo, Vitoria, ES, Brazil.

Lipids in Health and Disease
|November 29, 2011
PubMed
Summary

Hypercholesterolemia and aging significantly impair kidney function in mice. These conditions reduce glomerular filtration rate and increase urea, mesangial expansion, and fibrosis, highlighting their combined negative impact on renal health.

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Area of Science:

  • Nephrology
  • Gerontology
  • Cardiovascular Science

Background:

  • Aging and dyslipidemia are risk factors for kidney disease.
  • Understanding their combined impact on renal function is crucial for developing preventative strategies.

Purpose of the Study:

  • To investigate the effects of hypercholesterolemia and aging on renal function in mice.
  • To assess changes in glomerular filtration rate, kidney structure, and molecular markers.

Main Methods:

  • Male apolipoprotein E-deficient (ApoE) and C57BL/6 mice were studied at young (2 months) and adult (8 months) ages.
  • Renal function was assessed via creatinine clearance, serum urea, and urinary creatinine.
  • Kidney tissue was analyzed for mesangial expansion, fibrosis, and neuronal nitric oxide synthase (nNOS) expression.

Main Results:

  • ApoE mice exhibited significantly higher total cholesterol and urea levels compared to controls.
  • Glomerular filtration rate (GFR) was reduced in ApoE mice at both ages and in aged C57BL/6 mice.
  • Mesangial expansion and tubulointerstitial fibrosis were increased in ApoE mice, worsening with age. nNOS expression decreased over time in both strains.

Conclusions:

  • Both hypercholesterolemia and aging contribute to renal function decline in mice.
  • The study demonstrates a synergistic negative effect of these conditions on kidney health.