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QT dispersion is not increased in familial Mediterranean fever

F Topal1, A Tanindi, H G Kurtoglu

  • 1Department of Gastroenterology, Cankiri State Hospital, Cankiri, Turkey.

The Journal of International Medical Research
|November 29, 2011
PubMed

Insights

Familial Mediterranean fever (FMF) does not significantly affect electrocardiographic ventricular repolarization parameters like QT interval and QT dispersion. This suggests these ECG measures have limited value in assessing cardiac risk in FMF patients.

Area of Science:

  • Cardiology
  • Genetics
  • Immunology

Background:

  • Familial Mediterranean fever (FMF) is an autosomal recessive autoimmune disease.
  • FMF presents with recurrent fever and polyserositis.
  • Cardiac involvement in FMF requires further investigation.

Purpose of the Study:

  • To investigate electrocardiographic ventricular repolarization parameters in FMF patients.
  • To assess QT interval and QT dispersion in FMF.
  • To determine the value of these ECG parameters for cardiac risk evaluation in FMF.

Main Methods:

  • Electrocardiographic ventricular repolarization parameters, including QT interval and QT dispersion, were measured.
  • QT interval was manually measured from QRS onset to T wave end.
  • Corrected QT was calculated using the Bazett formula; QT dispersion was defined as max-min QT values.

Main Results:

  • No significant differences were observed in QT interval or QT dispersion between FMF patients and healthy controls.
  • Ventricular repolarization parameters were not significantly affected by FMF.
  • QT dispersion was found to be unaffected in FMF patients.

Conclusions:

  • Electrocardiographic assessment of QT interval and QT dispersion holds limited value for evaluating cardiac impairment in FMF patients.
  • These ECG parameters are of little value for assessing arrhythmia risk in FMF.
  • Further research may be needed to identify reliable cardiac risk markers in FMF.

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