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Designer polymer-based microcapsules made using microfluidics.

Philipp W Chen1, Randall M Erb, André R Studart

  • 1Complex Materials, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland.

Langmuir : the ACS Journal of Surfaces and Colloids
|November 29, 2011
PubMed
Summary
This summary is machine-generated.

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Microfluidic devices create polymer microcapsules with tunable properties for drug delivery. Design maps predict capsule size and shell thickness, enabling controlled mechanical characteristics for triggered release applications.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biomedical Engineering

Background:

  • Microfluidic devices enable precise fabrication of microcapsules for diverse applications.
  • Controlling microcapsule properties is challenging due to numerous interdependent variables.

Purpose of the Study:

  • To develop quantitative design maps for microcapsule fabrication using microfluidics.
  • To correlate fabrication parameters with microcapsule size, shell thickness, and mechanical properties.

Main Methods:

  • Fabrication of water-in-oil-in-water double emulsion templates in microcapillary devices.
  • In situ photopolymerization of the middle oil phase to form polymer shells.
  • Single capsule compression testing to evaluate mechanical properties (elastomeric to brittle).

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Last Updated: May 27, 2026

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Published on: October 13, 2021

Microfluidic Preparation of Liquid Crystalline Elastomer Actuators
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Published on: May 20, 2018

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  • Statistical analysis of capsule rupture under load.

    • Main Results:

    • Quantitative design maps correlating flow rates and device geometry with capsule size and shell thickness.
    • Tunable mechanical properties of hollow capsules achieved by selecting polymers with specific glass transition temperatures.
    • Demonstrated control over capsule shell permeability and microstructure via cross-linkers and silica nanoparticles.

    Conclusions:

    • Microfluidic fabrication offers predictable control over microcapsule dimensions and mechanical properties.
    • Tunable capsules are suitable for applications requiring specific mechanical responses, such as triggered release.
    • Microstructure modification allows further tailoring of capsule functionality for advanced delivery systems.