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Updated: May 27, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array

Ivo Kwee1, Andrea Rinaldi, Paola Rancoita

  • 1Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland. ivo.kwee@irb.unisi.ch

British Journal of Haematology
|November 29, 2011
PubMed
Summary

The Illumina Infinium Methylation assay can estimate DNA copy number changes, a crucial factor in cancer development. This finding offers a dual-purpose tool for analyzing both methylation and copy number in tumors.

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...