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Updated: May 27, 2026

Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat
Published on: February 7, 2011
[Congenital hyperinsulinism--new causes and clinical variations]
Maria Fuglsang Bruun1, Stine Hedegaard Christoffersen, Klaus Brusgaard
1Det Sundhedsvidenskabelige Fakultet, Syddansk Universitet, Denmark.
Abstract:
Congenital hyperinsulinism (CHI) is a heterogeneous disease with variable onset, non- or hypoketotic hypoglycaemia, onset from birth to adulthood and a persistent, intermittent, or transient course with possible later conversion to non-autoimmune diabetes. Giving insights to beta cell function, CHI mutations are now known in eight genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A and UCP2). However, 40-50% of the patients are still genetically unexplained. CHI can be dominantly or recessively inherited or may occur de novo. A number of syndromes can be associated with CHI.
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