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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Acute lymphoblastic leukemia.

Christine J Harrison1

  • 1Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Level 5 Sir James Spence Institute, Royal Victoria Infirmary, Newcastle-upon-Tyne NE1 4LP, UK. christine.harrison@newcastle.ac.uk

Clinics in Laboratory Medicine
|November 29, 2011
PubMed
Summary
This summary is machine-generated.

Precursor B-acute lymphoblastic leukemia (BCP-ALL) in children has a good prognosis. Advanced genomic sequencing reveals new genetic markers that could lead to targeted therapies and improved outcomes for leukemia patients.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Genetics

Background:

  • Precursor B-acute lymphoblastic leukemia (BCP-ALL) in children generally has a favorable outcome.
  • Cytogenetics is a standard method for risk stratification in leukemia treatment, improving survival rates.
  • Genetic analysis in T-acute lymphoblastic leukemia (T-ALL) has advanced biological understanding, though not yet guiding therapy.

Purpose of the Study:

  • To explore the role of novel genetic changes in BCP-ALL.
  • To identify potential molecular targets for improved leukemia therapies.
  • To enhance understanding of the biological and clinical features of ALL.

Main Methods:

  • Utilizing state-of-the-art genomic and high-throughput targeted sequencing technologies.
  • Analyzing genetic alterations in leukemia samples.
  • Correlating genetic findings with biological and clinical features.

Main Results:

  • Discovery of novel genetic changes associated with specific biological and clinical characteristics in ALL.
  • Identification of potential new biomarkers for risk stratification and therapeutic targeting.
  • Advancement in understanding the genetic landscape of leukemia.

Conclusions:

  • Genomic technologies are crucial for uncovering new insights into ALL biology.
  • Novel genetic biomarkers hold promise for developing targeted therapies.
  • Further research can lead to improved survival and quality of life for ALL patients.