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Updated: Jan 20, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Chronic myeloid leukemia: current perspectives
Yanming Zhang1, Janet D Rowley
1Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry Building 7-729, Chicago, IL 60611, USA. yanming-zhang@northwestern.edu
Abstract:
Chronic myeloid leukemia (CML), characterized by the t(9;22) and BCR/ABL1 fusion, is a disease model for studying the mechanisms of genetic abnormalities in leukemogenesis. The detection of the t(9;22), characterization of the BCR/ABL fusion, and the discovery of imatinib have elegantly reflected the success of our research efforts in CML. However, genomic instabilities that lead to the formation of the BCR/ ABL1 fusion are not fully understood. It is important to understand how various genes that are involved in regulating the signaling pathway and epigenetic deregulation cooperate with the BCR/ABL1 fusion in the initiation and progression of CML.
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