The correlation between metabolic syndrome and prostatic diseases.
Cosimo De Nunzio1, William Aronson, Stephen J Freedland
1Department of Urology, Sant'Andrea Hospital, University La Sapienza, Rome, Italy. cosimodenunzio@virgilio.it
European Urology
|November 29, 2011
Summary
Metabolic syndrome (MetS) is linked to prostate diseases like benign prostatic hyperplasia (BPH) and prostate cancer (PCa). While evidence suggests an association, more research is needed to confirm a causal link and understand its role in treatment.
Area of Science:
- Urology
- Endocrinology
- Public Health
Background:
- Metabolic syndrome (MetS) is a global epidemic characterized by metabolic abnormalities.
- Growing evidence links MetS to the development and progression of prostate diseases, including benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
Purpose of the Study:
- To review the existing evidence on the role of MetS in BPH and PCa.
- To discuss the clinical implications for managing, preventing, and treating these prostate conditions.
Main Methods:
- A comprehensive literature search was conducted using PubMed (1995-2011).
- Keywords included 'metabolic syndrome,' 'prostate,' 'benign prostatic hyperplasia,' 'prostate cancer,' and related terms.
Main Results:
- MetS is a prevalent, complex disorder with key components including central obesity, insulin resistance, dyslipidemia, and hypertension.
- An association between MetS and the initiation/progression of BPH and PCa is increasingly evident, though underlying mechanisms and treatment effects are unclear.
Conclusions:
- Current literature suggests a correlation between MetS and BPH/PCa, but a definitive causal relationship is yet to be established.
- MetS represents a significant area for future basic and clinical research in urology.
Related Concept Videos
01:20Disorders of the Male Reproductive System
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:21Nursing Assessment of the Genitourinary System I: Health History
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...