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Updated: May 27, 2026
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Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
Duodenal gastrointestinal stromal tumor
Gh Ghidirim1, I Mishin, I Gagauz
1Nicolae Anestiadi First Department of Surgery and Laboratory of Hepato-Pancreato-Biliary Surgery, Nicolae Testemitanu Medical University, National Center of Emergency Medicine, Kishinev, Moldova.
Summary
Gastrointestinal stromal tumors (GISTs) are rare duodenal tumors. Surgical resection is effective for localized GISTs, with partial duodenectomy being a viable oncologic option.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Oncology
Background:
- Gastrointestinal stromal tumors (GISTs) are uncommon malignancies arising in the digestive tract.
- Duodenal GISTs represent a small subset, approximately 4.5% of all GISTs.
- Historically misdiagnosed as leiomyomas or leiomyosarcomas.
Observation:
- A case of a patient presenting with upper gastrointestinal bleeding.
- Radiological imaging revealed a tumor in the third portion of the duodenum.
- The patient underwent a successful segmental duodenectomy.
Findings:
- Pathological examination confirmed the diagnosis of a GIST.
- The patient has remained recurrence-free for one year post-surgery.
Implications:
- Surgical resection is the primary treatment for localized GISTs.
- Partial duodenectomy is a feasible alternative to more extensive procedures like duodenopancreatectomy for duodenal GISTs.
- This case underscores the importance of considering GIST in the differential diagnosis of duodenal tumors presenting with bleeding.