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Updated: May 27, 2026

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
From skeletal muscle to cancer: insights learned elucidating the function of tropomyosin
Cheolwon Choi1, Dayoung Kim, Sabina Kim
1Department of Biological Sciences, Korean Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Abstract:
The tropomyosins (Tms) are a family of actin filament binding proteins that possess a simple dimeric α-helical coiled-coil structure along their entire length. Our knowledge of Tm structure and function has greatly expanded since they were first discovered in skeletal muscle almost 65 years ago. In multicellular organisms they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its significance to actin-based cellular functions.
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