Clinical course of children with HIV associated thrombocytopenia

To study the clinical profile of HIV associated thrombocytopenia, co-relation between thrombocytopenia and immune status and the effect of the anti-retroviral therapy (ART) on platelet count.

In this cross sectional retrospective analytical study, records of all children up to 15 y, enrolled at a Pediatric ART Centre during the period 30 Nov. 2006 to 31st Dec. 2009 were reviewed for presence of thrombocytopenia. Clinical course, outcome and their immunological status were analyzed.

34 children (19.6%) out of 173 were found to have thrombocytopenia. After excluding three who had pancytopenia associated thrombocytopenia, records of 31 children (28 M, 3 F) were further studied. Six children (19.4%) presented with bleeding manifestations. The platelet counts ranged between 4x10(9)/L to 140x10(9)/L. No specific co-relation could be made out between platelet count and CD4 counts. The mortality was higher in thrombocytopenic children on ART as compared to children on ART with normal platelet count (p- < 0.001). Amongst the live children, the platelet counts normalized within 3 mo of ART in 11 (64.7%) while it took 18 mo in three and 30 mo in one case respectively. Twelve children with thrombocytopenia as an incidental finding have shown a good platelet response to ART. Six symptomatic children with thrombocytopenia showed a varied platelet response to ART despite showing a significant increase in the CD4 counts.

Thrombocytopenia in HIV infected may be an incidental finding in some children. Thrombocytopenia was found to be a poor prognostic factor and no specific co-relation to immune status was seen.