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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Published on: July 24, 2019

Vascular parkinsonism: what makes it different?

Deepak Gupta¹, Abraham Kuruvilla

¹Division of Neurology, Department of Medicine, Walter C Mackenzie Health Sciences Center, University of Alberta, Edmonton, Canada. docdeepakgupta@gmail.com

Postgraduate Medical Journal

|November 29, 2011

Summary

Vascular parkinsonism (VP), a secondary form of parkinsonism, presents distinct symptoms like falls and gait issues, differing from Parkinson's disease (PD). Differentiating VP from PD is crucial for appropriate prognosis and treatment.

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Area of Science:

Neurology
Neuroscience
Geriatrics

Background:

Vascular parkinsonism (VP) constitutes 2.5-5% of parkinsonism cases.
VP results from ischemic cerebrovascular disease, classifying it as secondary parkinsonism.
It is also known as arteriosclerotic parkinsonism or vascular pseudo-parkinsonism.

Purpose of the Study:

To differentiate Vascular Parkinsonsim (VP) from Parkinson's Disease (PD).
To highlight the clinical features and diagnostic methods for VP.
To discuss the therapeutic implications for VP patients.

Main Methods:

Clinical feature analysis comparing VP and PD.
Review of diagnostic criteria for VP.
Assessment of levodopa response in VP.

Main Results:

VP typically presents with postural instability and falls, unlike the upper limb rest tremor in PD.
VP exhibits a parkinsonian-ataxic gait, pyramidal signs, and early subcortical dementia.
Brain MRI can reveal white matter lesions or subcortical infarcts, supporting a VP diagnosis.
A poor or non-sustained response to levodopa is characteristic of VP.

Conclusions:

Distinguishing VP from PD is essential due to differing prognoses and treatments.
Clinical presentation, gait characteristics, and MRI findings aid in VP diagnosis.
Limited therapeutic response to levodopa further differentiates VP from PD.