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Related Experiment Video

Updated: May 27, 2026

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Primary pigmented nodular adrenocortical disease.

Marie T Manipadam¹, Rachel Abraham, Sudipta Sen

¹Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Journal of Indian Association of Pediatric Surgeons

|November 29, 2011

Summary

Primary pigmented nodular adrenocortical disease (PPNAD) causes ACTH-independent Cushing's syndrome. This report details a case in a boy, highlighting bilateral adrenalectomy as the preferred treatment.

Keywords:

Cushing's syndrome primary pigmented nodular adrenocortical disease

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Published on: March 12, 2019

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A Novel Method: Super-selective Adrenal Venous Sampling

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Published on: September 15, 2017

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Area of Science:

Endocrinology
Pathology
Pediatric Medicine

Background:

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare endocrine disorder.
It is a significant cause of ACTH-independent Cushing's syndrome.
PPNAD presents with distinct pathological features.

Observation:

A case of PPNAD in a 15-year-old male patient is presented.
This specific case was not associated with Carney's complex.
The patient exhibited characteristic gross and microscopic findings of PPNAD.

Findings:

The study confirms PPNAD as a cause of ACTH-independent Cushing's syndrome.
The absence of Carney's complex in this pediatric case is noted.
Pathological examination revealed typical PPNAD characteristics.

Implications:

This case contributes to understanding PPNAD in pediatric populations.
It reinforces the diagnostic criteria for PPNAD.
Bilateral adrenalectomy is confirmed as the primary therapeutic option for PPNAD.