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Hyperglycemic hyperosmolar state associated with low-dose quetiapine treatment in a patient with bipolar disorder
Wen-Yin Chen1, Chiao-Chicy Chen, Galen C L Hung
1Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
Abstract:
There is increasing concern about the development of diabetes mellitus and associated complications in patients administrating second-generation antipsychotics. Previous reports indicate that the risk of quetiapine, although relatively lower, is not negligible. We report a patient with bipolar disorder who, after treating with low-dose quetiapine, develops newly-onset diabetes and hyperglycemic hyperosmolar state. Clinical manifestations and managements of quetiapine-associated diabetes are addressed, and we recommend routine monitoring of serum glucose after initiating quetiapine treatment at any given dose.
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