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Breast arterial calcification and hypertension associated with vertebral fracture

Hiroshi Wada1, Fuminori Hirano, Tatsuhiko Kuroda

  • 1Wada Women's Clinic, Asahikawa Medical College, Asahikawa, Japan. wada@potato.hokkai.net

Geriatrics & Gerontology International
|November 30, 2011
PubMed

Insights

Hypertension and breast arterial calcifications (BAC) are significant risk factors for vertebral fractures in Japanese postmenopausal women. These conditions, along with osteoporosis, may share common underlying metabolic pathways.

Area of Science:

  • Endocrinology
  • Gerontology
  • Cardiovascular Medicine

Background:

  • Arterial calcification and osteoporosis are common comorbidities in postmenopausal women.
  • Hypertension is a known contributor to arterial calcification.

Purpose of the Study:

  • To investigate the associations between hypertension, arterial calcification, and vertebral fractures.
  • Cross-sectional study in Japanese postmenopausal women.

Main Methods:

  • Medical histories of 421 postmenopausal Japanese women were reviewed.
  • Measurements included body weight, height, and bone mineral density (BMD).
  • Vertebral fractures diagnosed via semiquantitative method; breast arterial calcifications (BAC) assessed by mammography.

Main Results:

  • Vertebral fracture patients were older, shorter, had lower BMD, and more BAC.
  • Higher prevalence of hypertension observed in patients with vertebral fractures.
  • Independent risk factors for vertebral fractures: age, BAC, and hypertension.

Conclusions:

  • First report on the relevance of BAC and hypertension to vertebral fractures in Japanese women.
  • Suggests a shared common metabolic pathway for hypertension, BAC, and osteoporotic fractures.
Abstract

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